Raph
je viens de regarder la littérature scientifique et c'est 4 jours pour perdre 99% de la tolérance mdr
https://maps.org/research[...]8/2008_Passie_23067_1.pdf
Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the effects of LSD occurs in humans and animals. Tolerance to autonomic and psychological effects of LSD occurs in humans after a few moderate daily doses of LSD [42,163,164]. Abramson et al. [163] gave 5–100 μg LSD p.o. for 3–6 days to healthy volunteers. After 2–3 days, a solid tolerance developed as demonstrated in psychological and physiological tests. After tolerance to LSD is achieved and placebo instead of LSD is given for the next 3 days, the typical LSD effects will finally reoccur on the fourth day [42].
A recent animal experiment with rats (130 μg/kg LSD i.v. for 5 consecutive days), who were previously trained to discriminate LSD from saline, indicated a decrease in 5-HT2A receptor signaling caused by a reduction of 5-HT2A receptor density [165]. This reduction in receptor density may point to a possible mechanism for the development of acute tolerance to LSD.
Pretreatment with BOL-148, a nonhallucinogenic congener of LSD with serotonin antagonist properties like LSD, [166] will not block the effects of LSD [167,168]. But other derivates of LSD, such as UML-491 and MLD- 41, are able to induce cross-tolerance if applied in the days prior to LSD [167].
There is partial cross-tolerance (depending on whether LSD is given first or second) among LSD, mescaline, and psilocybin [168–170]. The most complete cross- tolerance is to mescaline in LSD-tolerant subjects. One study suggested that one-way cross-tolerance from LSD to DMT does not occur [171]. Studies with -9- tetrahydrocannabiol (THC) in subjects tolerant to LSD did not demonstrate a cross-tolerance between these drugs [172,173]. There is no cross-tolerance between LSD and amphetamine [169]. See Wyatt et al. [174] and Hintzen [50] for a complete review of tolerance and cross-tolerance studies with LSD.
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gros je te dirais
https://maps.org/research[...]8/2008_Passie_23067_1.pdf
Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the effects of LSD occurs in humans and animals. Tolerance to autonomic and psychological effects of LSD occurs in humans after a few moderate daily doses of LSD [42,163,164]. Abramson et al. [163] gave 5–100 μg LSD p.o. for 3–6 days to healthy volunteers. After 2–3 days, a solid tolerance developed as demonstrated in psychological and physiological tests. After tolerance to LSD is achieved and placebo instead of LSD is given for the next 3 days, the typical LSD effects will finally reoccur on the fourth day [42].
A recent animal experiment with rats (130 μg/kg LSD i.v. for 5 consecutive days), who were previously trained to discriminate LSD from saline, indicated a decrease in 5-HT2A receptor signaling caused by a reduction of 5-HT2A receptor density [165]. This reduction in receptor density may point to a possible mechanism for the development of acute tolerance to LSD.
Pretreatment with BOL-148, a nonhallucinogenic congener of LSD with serotonin antagonist properties like LSD, [166] will not block the effects of LSD [167,168]. But other derivates of LSD, such as UML-491 and MLD- 41, are able to induce cross-tolerance if applied in the days prior to LSD [167].
There is partial cross-tolerance (depending on whether LSD is given first or second) among LSD, mescaline, and psilocybin [168–170]. The most complete cross- tolerance is to mescaline in LSD-tolerant subjects. One study suggested that one-way cross-tolerance from LSD to DMT does not occur [171]. Studies with -9- tetrahydrocannabiol (THC) in subjects tolerant to LSD did not demonstrate a cross-tolerance between these drugs [172,173]. There is no cross-tolerance between LSD and amphetamine [169]. See Wyatt et al. [174] and Hintzen [50] for a complete review of tolerance and cross-tolerance studies with LSD.
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mais crois moi demain tu seras calmé
gros je te dirais
