Citation de BrotherLime
J'ai trouvé pas mal d'élément qui confirme que la protéines Spike agit bien sur les récepteurs ACE2, notamment ici https://www.ahajournals.o[...]161/CIRCRESAHA.121.318902

mais rien qui indique qu'elle serait inerte en stade pré-fusion. Je comprend pas besoin ton litige avec ce qui est dit dans la vidéo sur ce point en particulier (on va pas parler des autres points évidement).

De ce que j'en sais, la protéine spike du vaccin au stade pré-fusion ne peut pas se lier au récepteur ACE2 afin de fusionner avec la cellule, d'où l'intérêt de la manoeuvre.

The binding of RBM to the ACE2 receptor is crucial in the viral infection process, since it has been shown that this interaction induces the transition of S from a metastable prefusion state to a more stable post-fusion state, which is required for membrane fusion between the virus and the host cell.
https://www.frontiersin.o[...]89/fimmu.2021.701501/full

We have assessed the results of immunization in a mouse model using an S protein trimer stabilized in the closed state to prevent full exposure of the receptor binding site and therefore interaction with the receptor. [...] Notably, the protein binding properties of sera induced by the closed spike differed from those induced by standard S protein constructs. Closed S proteins induced more potent neutralizing responses than expected based on the degree to which they inhibit interactions between the RBD and ACE2.
https://journals.asm.org/doi/10.1128/JVI.00203-21